A medicament delivery tray and method for treating periodontal disease include fitting of a tray about the teeth and gums wherein the tray includes a seal that creates a substantially airtight seal against the gumline and a substantially airtight treatment chamber about the enclosed teeth and gums, the tray further having a reinforcing skirt providing a biasing force to the seal wherein a positive pressure can be created in the treatment chamber for forcing a medicament into the gums about the enclosed teeth.