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Condensed pyridine compounds as CB2 cannabinoid receptor ligands
专利权人:
Astellas Pharma Inc.
发明人:
MATSUSHIMA, Yuji,KAMEDA, Minoru,HONDA, Shugo,SUGANO, Yukihito,USUDA, Hiroyuki,TERASAKA, Tadashi,TERASAWA, Takeshi,NISHIGAKI, Fusako
申请号:
ES11812552
公开号:
ES2592161T3
申请日:
2011.07.28
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of Formula (I) or a salt thereof, ** Formula ** (in which, X and Y represent CH, C-lower alkyl or N, in which either X or Y represents N, W represents - NH-, -N (lower alkyl) -, -O-, -S-, -S (O) - or -S (O) 2-, R1 represents cycloalkyl which may be substituted with one or more substituents selected from the group D, aryl that may be substituted with one or more substituents selected from group D, an aromatic heterocycle that may be substituted with one or more substituents selected from group D or a non-aromatic heterocycle that may be substituted with one or more selected substituents Among the group D, R2 represents -Z-NR3R4 or -Z-cyclic amino which may be substituted with one or more substituents selected from group D, and group D includes (1) halogen, (2) -OH and -SH , (3) cyano and nitro, (4) cycloalkyl, -O-cycloalkyl and -C (O) -cycloalkyl, which may be respectively substituted with one or more groups selected from the group consisting of lower alkyl, halogen, -OH, -O-lower alkyl, - O-halogen-lower alkyl and halogen-lower alkyl, (5) aryl, -O-aryl and -C (O) -aryl, which may be respectively substituted with one or more groups selected from the group consisting of lower alkyl, halogen, -OH, -O-lower alkyl, -O-lower halogenoalkyl and lower halogen-alkyl, (6) an aromatic heterocycle, - O-aromatic heterocycle and -C (O)-aromatic heterocycle, which may be respectively substituted with one or more groups selected from the group consisting of lower alkyl, halogen, -OH, -O-lower alkyl, -O-halogen- lower alkyl and halogen-lower alkyl, (7) a non-aromatic heterocycle, -O-non-aromatic heterocycle and -C (O) -non-aromatic heterocycle, which may be respectively substituted with one or more groups selected from the group consisting of lower alkyl, halogen, -OH, -O-lower alkyl, -O-halogen-lower alkyl and halog eno-lower alkyl, (8) -C (O) -alkyl, -C (O) O-lower alkyl, -NH-C (O) -alkyl, -NH-lower alkyl, -N (lower alkyl) 2, -CONH-lower alkyl and CON (lower alkyl) 2, wh
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