591896 COMPOSITIONS AND METHODS OF TREATING AMYLOID DISEASE The disclosure is directed to compounds of formulas Ia, Ib and Ic that inhibit amyloid aggregation and methods of treatment therewith. Examples of the claimed compounds include: N-methyl-5-(4-benzoylpiperazin-1-yl)-2-nitro-N-phenylbenzenamine, 2-(benzyl amino)-N,N-dimethyl-4-(4-benzoylpiperazin-1-yl)benzamide, 2-(benzylamino)N-ethyl-4-(4-benzoylpiperazin-1-yl)benzamide, 4-(4-benzoylpiperazin-l-yl)-N1-(2-morpholinoethyl)-N2-phenylbenzene-1,2-diamine, (4-(3-(N-methyl-N-phenylamino)-4-(dimethyl amino )phenyl)piperazin-1-yl)(phenyl)methanone and [4-(1, 1-dimethylethyl)phenyl][4-[4-nitro-3-[(phenylmethyl)amino]phenyl]-1-piperazinyl]methanone. The compounds are used in treatment of Alzheimers disease, Parkinsons disease, Huntingtons disease, and prion diseases.
