ANN-MARIE CAMPBELL,ANNA ERICSSON,DAVID R. LANCIA,GARY GUSTAFSON,JIAN LIN,JUSTIN ANDREW CARAVELLA,R. BRUCE DIEBOLD,SUSAN ASHWELL,WEI LU,ZHONGGUO WANG
申请号：
BR112017005238
公开号：
BR112017005238A2
申请日:
2015.09.18
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The invention relates to inhibitors of mutant isocitrate dehydrogenase proteins (mt-idh) with neomorphic activity useful in the treatment of cell proliferation disorders and cancers, having the formula: (i), wherein a, u, w1, w2, w3 , r1-r6 and r9 are described herein.a invenção refere-se a inibidores das proteínas isocitrato desidrogenase mutantes (mt-idh) com atividade neomórfica útil no tratamento de distúrbios de proliferação celular e cânceres, tendo a fórmula: (i), em que a, u, w1, w2, w3, r1-r6 e r9 são descritos neste documento.
