НОПФ Джон (US),СИХРА Джасбир (US),КУМАР Равиндра (US)
申请号：
RU2012129353/15
公开号：
RU2012129353A
申请日:
2012.07.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A method of treating or preventing breast cancer in a human patient, the method comprising administering to the patient an effective amount of an ActRIIa-Fc.2 fusion protein. The method of claim 1, wherein the ActRIIa-Fc fusion protein is selected from the group consisting of: a. a polypeptide containing an amino acid sequence of at least 90% identical to SEQ ID NO: 2 b. a polypeptide containing an amino acid sequence of at least 90% identical to SEQ ID NO: 3； c. a polypeptide containing at least 50 consecutive amino acids of SEQ ID NO: 2.3. The method of claim 1, wherein the ActRIIa-Fc fusion protein has one or more of the following characteristics: i. binds to an ActRIIa ligand with K of at least 10M； and ii. inhibits the ActRIIa signaling pathway in the cell. 4. The method of claim 1, wherein said ActRIIa-Fc fusion protein contains one or more modified amino acid residues selected from: a glycosylated amino acid, a pegylated amino acid, a farnesylated amino acid, an acetylated amino acid, a biotinylated amino acid, a lipid-conjugated amino acid, and a conjugated amino acid with organic derivative. 5. The method of claim 2, wherein the ActRIIa-Fc fusion protein contains an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 2.6. The method of claim 2, wherein the ActRIIa-Fc fusion protein contains an amino acid sequence that is at least 95% identical to the amino acid sequence of SEQ ID NO: 3.7. The method of claim 6, wherein the ActRIIa-Fc fusion protein comprises the amino acid sequence of SEQ ID NO: 3.8. The method according to claim 5, where the ActRIIa-Fc fusion protein contains amino acid after1. Способ лечения или профилактики рака молочной железы у пациента-человека, причем данный способ включает введение пациенту эффективного количества слитого белка ActRIIa-Fc.2. Способ по п.1, где слитый белок ActRIIa-Fc выбран из группы, состоящей из:a. полипептида, содержащего аминокислотную последовательность по меньшей мере
