A human tissue quasi-elastic coefficient measurement method, wherein a simplex optimization method is used to determine human tissue quasi-elastic coefficients, and nine elastic coefficients in three dimensions are reduced to three quasi-elastic coefficients (for two-dimensional ultrasound patient treatment planning or probing, four elastic coefficients are reduced to two quasi-elastic coefficients), thereby saving calculation time. Also provided is a human tissue quasi-elasticity measurement method based on the human tissue quasi-elastic coefficient measurement method, wherein a secondary imaging method is used to measure relative changes in human tissue quasi-elastic coefficients, thereby improving defects in elasticity imaging devices which are dependent on ultrasound imaging accuracy. Changes in human tissue structures may be accurately determined by measuring the relative changes. Also provided is an ultrasound probe or probing device matched with the human tissue quasi-elastic coefficient measurement, which obviates the need for expensive imaging devices, thereby lowering costs.