The present invention relates to tosilate and crystalline form of MEK inhibitor and preparation methods thereof. Particularly relates to 2-((2-fluoro-4-iodophenyl)amino) -1-methyl-4-((6-methylpyridin-3-yl)oxy)-6-oxo-1,6-dihydropyridine-3-carboxamide tosylate (formula (I)) and form I crystal and preparation methods thereof. The form I crystal in this invention has good polymorph stability and chemical stability, furthermore, the solvent used for crystallization is low toxicity and low residual, so it can be better used for clinical treatment.本發明涉及一種MEK激酶抑制劑的對甲苯磺酸鹽、其結晶形式及製備方法。具體地,本發明涉及2-((2-氟-4-碘苯基)胺基)-1-甲基-4-((6-甲基吡啶-3-基)氧基)-6-羰基-1,6-二氫吡啶-3-甲醯胺對甲苯磺酸鹽(式(I)化合物)、其I型結晶及其製備方法。本發明所得到式(I)化合物的I型結晶具備良好的晶型穩定性和化學穩定性,並且所用結晶溶劑低毒低殘留,可更好地用於臨床治療。
