PROBLEM TO BE SOLVED: To provide a technique of suppressing discoloration of an aqueous composition containing a halogenated isoquinoline derivative when stored at high temperature.SOLUTION: A pharmaceutical preparation for prevention or treatment of at least one disease selected from ocular hypertension and glaucoma is formed by accommodating an aqueous composition comprising ripasudil or a salt thereof, or a solvate thereof in a container made of at least one polyolefin resin selected from polyethylene and polypropylene.SELECTED DRAWING: None【課題】ハロゲン化イソキノリン誘導体含有水性組成物の、高温保存時の変色を抑制する技術を提供すること。【解決手段】リパスジル若しくはその塩又はそれらの溶媒和物を含有する水性組成物が、ポリエチレン及びポリプロピレンから選ばれる１種以上のポリオレフィン系樹脂製容器に収容されてなる、高眼圧症及び緑内障から選ばれる１種以上の疾患の予防又は治療用の医薬製剤。【選択図】なし
