A substance is disclosed for preventing, delaying the onset of or treating one or more than one autoimmune disease, the substance comprising a combination of a polynucleotide construct comprising a polynucleotide sequence encoding ”BCL-2 and encoding one or more than one autoantigen for the autoimmune disease. A use is also disclosed of a polynucleotide construct comprising a combination of a polynucleotide construct comprising a polynucleotide sequence encoding ”BCL-2 and encoding one or more than one autoantigen for the autoimmune disease, for the manufacture of a medicament for preventing, delaying the onset of or treating one or more than one autoimmune disease.