The present invention provides with a novel fused bicyclic compound [I],wherein the ring A is a benzene ring having a substituent R1and optionally substituted with a substituent other than R1, which is fused with an adjacent 6-membered heterocyclic ring R1is an alkylsulfonylamino group etc. R2and R3are a) the same or different, hydrogen, an alkyl group, a substituted or unsubstituted aryl group, b)combined to form an oxo group, or c)combined each other together with an adjacent carbon atom to form a cycloalkyl group X is =N-, =C(R4)- or -CH(R4)-, R4is a) hydrogen, b) cyano, c) halogen, d) alkyl, e) alkenyl, f) cycloalkyl, g) alkanoyl, h) carbamoyl or i) cycloalkenyl Ar is a substituted or unsubstituted aromatic cyclic group and the dotted line means an existence or non-existence of a double bond, or a pharmaceutically acceptable salt thereof, which has an affinity to a receptor of mineral corticoid (MR) and useful as a hypotensive agent etc.本發明提供下列式[I]所表示的新穎稠合二環式化合物或其藥理上可容許的鹽,係對礦質類皮質素受體(MR)有親和性,有用於做為降壓劑等用途。[式中,環A為與相鄰的雜6員環縮合,具有取代基R1的苯環,亦可具有R1以外的取代基,R1為烷基磺醯基胺基等,R2及R3為(a)相同或不相同,而為氫、烷基、取代或無取代的芳基,或(b)二者一起成為酮基,或(c)二者相結合而與鄰接之碳原子共同形成環烷基,X為以式=N-、=C(R4)-或-CH(R4)-表示的基,R4為(a)氫、(b)氰基、(c)鹵素、(d)烷基、(e)烯基、(f)環烷基、(g)烷醯基、(h)胺甲醯基或(i)環烯基,Ar表示取代或無取代的芳族環式基,虛線表示雙鍵的存在或不存在。]
