A coated tablet formulation is provided which includes a medicament such as the DPP4-inhibitor, saxaglipitinor its HCl salt,which is subject to intra-molecular cyclization, which formulation includes a tablet core containing one or more fillers, and other conventional excipients, which tablet core includes a coating thereon which may include two or more layers, at least one layer of which is an inner seal coat layer which is formed of one or more coating polymers, a second layer of which is formed of medicament which is the DPP4-inhibitor and one or more coating polymers, and an optional, but preferable third outer protective layer which is formed of one or more coating polymers. A method for forming the coated tablet is also provided.本案提供一種加衣錠片調製物,其包括一藥物,諸如DPP4-抑制劑saxaglipitin或其HCl鹽,對其施予分子內環化,該調製物包括一錠片核(該核中含有一或多種填料,和其他習用之賦形劑,且在該錠片核上包括可能包括一或多層的塗層,其中至少一層為由一或多種塗覆聚合物所形成的內部封合塗層,該第二層係由DPP4抑制劑藥物和一或多種塗覆聚合物所形成,以及可選用但為較佳的由一或多種塗覆聚合物所形成之第二外部保護層。本案亦提供一種形成該加衣錠片之方法。
