Brian W. BUDZIK,Steven L. COLLETTI,Darla Danile SEIFRIED,Matthew G. STANTON,Lu TIAN
申请号：
US14325951
公开号：
US20140323548A1
申请日:
2014.07.08
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is more efficacious than traditional cationic lipids. The present invention employs amino alcohols to enhance the efficiency of in vivo delivery of siRNA.
