A collaborative automation platform and associated method include a fault-tolerant control server hosting one or more virtual controllers, and a fault-tolerant input/output server hosting a virtual input/output system. The collaborative automation platform also includes a master autonomous process interface system connected to the virtual input/output system, via a local area input/output network. The collaborative automation platform also includes a plurality of distributed autonomous process interface systems connected to the master autonomous process interface system, wherein each distributed autonomous process interface system is hardwired to a plurality of field instruments. The collaborative automation platform also includes real-time DDS middleware configured for execution with the fault-tolerant control server, the fault-tolerant input/output server, the master autonomous process interface system, and the plurality of distributed autonomous process interface systems.