Hawaii Biotech, INC.;Cardax Pharmaceuticals; Inc.;Cardax Pharmaceuticals, Inc.
发明人:
David G. Watumull,Geoff Nadolski,Henry Jackson,Laura M. Hix,Samuel Fournier Lockwood,Sean O'Malley,Sean OMalley
申请号：
BRPI0313155
公开号：
BRPI0313155B1
申请日:
2003.07.29
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
"chemical compound, pharmaceutical composition, methods for synthesizing a chemical compound to treat ischemia-reperfusion damage, liver disease, arrhythmia, and cancerous and precancerous cell (s) to enhance expression 43 and a disease with a chemical composition comprising a carotenoid derivative and to reduce a c-reactive protein. " method for inhibiting and / or improving the occurrence of diseases associated with reactive oxygen species reactive, radical and / or non-radical nitrogen species in an individual, thus an individual is administered with a carotenoid structural analog either alone or in combination another carotenoid analog, or co-antioxidant formulation. The analog or combination of analogs is administered such that the individual's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and / or non-radicals can thus be reduced. The analog or combination of analogs may be administered to an individual for the inhibition and / or amelioration of ischemia-reperfusion damage. The analog or combination of analogs may be administered to an individual for inhibiting and / or ameliorating liver disease. The analog or combination of analogs may be administered to an individual for inhibition and / or amelioration of cancer. The analog or combination of analogs may be administered to an individual for inhibiting and / or ameliorating cardiac arrhythmia and / or sudden cardiac death. The analog or combination of analogs may be administered to an individual for the inhibition and / or amelioration of any disease involving the production of reactive oxygen species, reactive nitrogen species, radicals and / or non-radicals. In one embodiment, a water-soluble and / or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination."composto químico, composição farmacêutica, métodos
