Systems and methods for non-vascular sensor implantation and for measuringphysiological parameters in areas of a body where the physiological parametersare heterogeneous. An implant unit is implanted in an area of a body and aforeign body capsule is allowed to form around the implant unit area. A sensormay be directed into a body cavity such as, for example, the peritoneal space,subcutaneous tissues, the foreign body capsule, or other area. A subcutaneousarea of the body may be tunneled for sensor placement. Spatially separatedsensing elements may be used for detecting individual amounts of thephysiological parameter. An overall amount of the physiological parameter maybe determined by calculating a statistical measurement of the individualsensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array onone side and an integrated circuit on another side.
