Allan Bradley,E-Chiang Lee,Qi Liang,Dominik Spensberger,Nicholas England
申请号：
US14226698
公开号：
US09963716B2
申请日:
2014.03.26
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates inter alia to improvements in the production of chimaeric antibodies in non-human transgenic vertebrates such as mice and rats bearing one or more chimaeric antibody transgenes. In particular, the invention provides for improved non-human vertebrates and cells in which VpreB has been species-matched with the variable region of the chimaeric antibodies. Also, embodiments also provide for species-matching of the entire surrogate light chain for efficient pairing with chimaeric heavy chains during B-cell development in vivo in a non-human transgenic vertebrate setting.
