A method for disrupting or destroying selected pathogens located within the body of an organism said method including the non-invasive administration to pre-selected locations on or in said organism of an amount of low intensity ultrasonic energy, effective to disrupt or destroy the selected pathogens but not deleteriously affect the organism, said low intensity ultrasonic energy falling within predefined ranges of frequencies, wherein said predefined range of frequencies is one or more ranges of frequencies at which the low intensity ultrasonic energy has optimal effectiveness in disrupting or destroying a particular pathogen, and the intensity of said low intensity ultrasonic energy falling within predefined ranges of intensity, wherein said predefined range of intensity of low intensity ultrasonic energy is such as to allow for disruption or destruction of said selected pathogens but not deleteriously affect tissue of the organism surrounding said selected pathogens.