A method is for operating a UV sterilization device including a housing defining a cavity, and having a door configured to permit access to the cavity, and trays carried within the cavity. Each tray is configured to receive a mobile wireless communications device. The UV sterilization device may include UV CBAs carried within the cavity respectively adjacent the trays, each UV CBA having LED UV sources configured to irradiate the mobile wireless communications device with UV radiation. The UV sterilization device may include a controller, and the method may include operating the controller to selectively power one of the UV CBAs for disinfecting the mobile wireless communications device.