The present invention pertains to: a ligand-binding molecule, the ligand binding activity of which is reduced by cleavage of a cleavage site thereof; a production method for the ligand-binding molecule; a complex formed of the ligand-binding molecule and a ligand; a fusion protein including the ligand-binding molecule and a ligand; and a pharmaceutical composition including the ligand-binding molecule, or including a fusion protein of the ligand-binding molecule and a ligand.