VERKADE JORGE MERIJN MATHIEU,WIJDEVEN MARIA ANTONIA,VAN DE SANDE PETRUS JOSEPHUS JACOBUS MARIA,VAN BERKEL SANDER SEBASTIAAN,VAN DELFT FLORIS LOUIS
申请号：
IN201717011607
公开号：
IN201717011607A
申请日:
2017.03.31
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention relates to a compound comprising an alpha end and an omega end the compound comprising on the alpha end a reactive group Qcapable of reacting with a functional group Fpresent on a biomolecule and on the omega end a target molecule the compound further comprising a group according to formula (1) or a salt thereof: Said compound may also be referred to as a linker conjugate. The invention also relates to a process for the preparation of a bioconjugate the process comprising the step of reacting a reactive group Qof a linker conjugate according to the invention with a functional group Fof a biomolecule. The invention further relates to a bioconjugate obtainable by the process according to the invention. In a preferred embodiment the invention concerns a process for the preparation of a bioconjugate via a cycloaddition such as a (4+2) cycloaddition (e.g. a Diels Alder reaction) or a (3+2) cycloaddition (e.g. a 1 3 dipolar cycloaddition).
