Georgia Regents University;H. Lee Moffitt Cancer Center and Research Institute, Inc.
发明人:
Paul Weinberger,De-Huang Guo,John Koomen
申请号：
US14992674
公开号：
US20160200804A1
申请日:
2016.01.11
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods of treating a disease or disorder characterized by cells with increased or aberrant expression of cytokeratin-8 (CK8) are disclosed. The methods typically include administering to a subject in need thereof a pharmaceutical composition including an effective amount of a CK8 inhibitor. Exemplary diseases include thyroid cancers, particularly thyroid cancers characterized by poorly differentiated or undifferentiated cells. In the most preferred embodiments the cancer is an anaplastic thyroid cancer or a poorly differentiated papillary thyroid cancer. Disclosed inhibitors include, functional nucleic acids, inhibitory anti-CK8 antibodies, inhibitory peptides, and small molecules.
