Systems and methods are disclosed for informing and monitoring blood flow calculations with user-specific activity data, including sensor data. One method includes receiving or accessing a user-specific anatomical model and a first set of physiological characteristics of a user； calculating a first value of a blood flow metric of the user based on the user-specific anatomical model and the first set of physiological characteristics； receiving or calculating a second set of physiological characteristics of the user by accessing or receiving sensor data of the user's blood flow and/or sensor data of the user's physiological characteristics； and calculating second value of the blood flow metric of the user based on the user-specific anatomical model and the second set of physiological characteristics of the user.
