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PROCÉDÉS DE CRIBLAGE À RÉCEPTEURS COUPLÉS À LA PROTÉINE G ET COMPOSITIONS APPARENTÉES
专利权人:
THE GENERAL HOSPITAL CORPORATION;CHUGAI PHARMACEUTICAL CO., LTD.
发明人:
申请号:
EP08794952.5
公开号:
EP2187902B1
申请日:
2008.08.01
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
The present invention relates to a polypeptide, or pharmaceutically acceptable salt thereof, comprising the formula PTH(1-X)/PTHrP(Y-36). Further, the present invention refers to a polypeptide which binds the PTH receptor and has a high affinity for the R 0 form of the PTH receptor and to a polypeptide having affinity for PTH RG and a low affinity for PTH R 0 . Moreover, the present invention includes to a pharmaceutical composition comprising such polypeptide. The present invention further relates to a polypeptide or a pharmaceutical composition of the present invention for use in a method for treating a disease or condition. Moreover, the present invention refers to a nucleic acid comprising a sequence encoding a polypeptide of the present invention, a vector comprising said nucleic acid, a cell comprising said vector and a method of making a polypeptide of the present invention. Finally, the present invention further relates to a method for determining whether a candidate compound is a long-acting agonist of a G protein coupled receptor (GPCR).
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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