An X-ray image diagnosis apparatus includes: an imaging unit supporting an X-ray generation unit and an X-ray detection unit to face each other to take an image of a subject placed on a bed top panel; a control unit to execute a step movement process of at least one of the imaging unit and top panel and take images of the subject at plural stages; and an image processing unit that processes image data taken at the plural stages. The control unit sets plural regions of interest (ROI) in an imaging area of the subject when an image is taken after a contrast medium is injected into the subject, measures a change of an image level in the ROI to detect a flow of the contrast medium, and makes at least one of the imaging unit and top panel move to the next imaging stage based on the detection result.