The present invention provides a method for treating inflammatory conditions, for example, inflammatory bowel disease, ulcerative colitis induced inflammatory bowel disease, spinal cord injury or spaceflight-induced immune dysregulation and associated comorbidities in a mammal or subject in need of such treatment. The present invention also provides a method for decreasing osteocyte protein levels in a mammal suffering from inflammatory condition. A pharmacologically effective does of Irisin or a pharmaceutical composition of irisin is administered to the mammal or subject one or more times.
