METHODS FOR INHIBITING NONALCOHOLIC STEATOHEPATITIS, NONALCOHOLIC FATTY LIVER DISEASE, AND/OR DE NOVO LIPOGENESIS

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专利权人:

The Regents of the University of California

发明人:

Michael Karin,Juyoun Kim

申请号：

US16483583

公开号：

US20190351003A1

申请日:

2018.02.07

申请国别(地区):

US

年份:

2019

代理人:

摘要：

Provided herein are methods of treating nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD), and/or elevated de novo lipogenesis (DNL) by inhibiting caspase-2 activity or expression. Also disclosed are methods of screening for agents useful in such methods.

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