Medicant mixing/administration systems are provided that can include: a medicant vial； a syringe assembly comprising a barrel and a piston； a protective material supporting the syringe assembly and medicant vial； and a member within the system, the member separating the piston of the syringe assembly from the medicant vial. Systems are provided that can include: a syringe assembly comprising a barrel and a piston； having a forward end and an opposing back end； a protective material supporting the syringe assembly； and a needle housing coupled to the protective material. Medicant mixing/administration methods are also provided that can include, within a package, sufficiently clearing a restraining member from between a medicant vial and syringe plunger to pierce the medicant vial with a piercing structure coupled to the syringe plunger, the piercing providing medicant from the vial to the syringe assembly. Additional methods can include, upon opening a package containing a syringe assembly, extending a needle housing from the package.
