#$%^&*AU2020200794A120200220.pdf#####Abstract The present disclosure describes a compositions and methods for treatment of Hras-driven cancers. 5 Administration of a farnesyltransferase inhibitor, for example, tipifarnib, alone or in combination with a MEK inhibitor can reduce tumor size and tumor growth in cancers such as poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) C: NRPortbI GHMatters MICHE LES 12016791_1.docx 9/01/2013/17 0 0) ' E 000 coo 0- 0 leA!AjunsIU03Jed