GHRELINE NON ACYLEE ET ANALOGUES EN TANT QU'AGENTS THERAPEUTIQUES POUR UN REMODELAGE VASCULAIRE CHEZ DES PATIENTS DIABETIQUES ET TRAITEMENT D'UNE MALADIE CARDIOVASCULAIRE
BRIZZI, MARIA FELICE,MUCCIOLI, GIAMPIERO,GHIGO, EZIO
申请号：
CA2723270
公开号：
CA2723270C
申请日:
2009.06.12
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to a method for treating a cardiovasculardisease, for increasing the number of circulatingangiogenic cells (CAC) and/or improving the function of CAC and a method forimproving vascular remodeling and/or neovascularisation.The method comprises administering to the subject a therapeutically effectiveamount of unacylated ghrelin or apolypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or afragment or analog thereof having the biologicalactivity of SEQ ID NO: 1； and to pharmaceutical compositions comprisingunacylated ghrelin or a polypeptide comprising theamino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereofhaving the biological activity of SEQ ID NO: 1.
