The invention relates to a medicament for treating pruritus and itch in a patient suffering from dermatological and non-dermatological conditions leading to such symptoms, which comprises at least one compound selected from a pyrone-indole derivative, in an effective amount, and optionally one or more other therapeutically active agents.本發明係關於用於治療患有引起搔癢症及發癢之皮膚病學及非皮膚病學病狀之患者之此等症狀之藥劑,其包含有效量之至少一種選自哌喃酮-吲哚衍生物之化合物及視情況一或多種其他治療活性劑。