PURPOSE: A calcitonin composition for oral administration is provided to enhance absorption of calcitonin which is hard to be absorbed in gastrointestinal tract.CONSTITUTION: A calcitoninin composition for oral administration contains: phospholipid with high transition temperature as a membrane ingredient of liposome cholesterol as a membrane ingredient of liposome anionic phospholipid as a membrane ingredient of liposome calcitonin which is encapsulated in liposome as an active ingredient and a mucoadhesive polymer as a liposome coating ingredient. The composition further contains one or more ingredients selected among folic acid-modified phospholipid and transferrin-modified phospholipid.COPYRIGHT KIPO 2013[Reference numerals] (AA) Calcium concentration in blood (% initial concentration) (BB) Time (h) (CC) Comparative example 1 (DD) Example 1 (EE) Example 2 (FF) Calcitoninin solution본 발명은 위장관에서 흡수가 어려운 펩타이드 약물인 칼시토닌의 흡수를 증진시킨 새로운 약제학적 조성물에 관한 것이다. 칼시토닌을 고전이온도 인지질, 콜레스테롤 및 음이온성 인지질을 이용하여 제조한 리포좀을 점막부착성 고분자로 코팅하여 제조한 약제학적 조성물에 관한 것이다. 본 발명의 조성물은 능동수송용 리간드 수식 인지질을 선택적으로 더 포함할 수 있다.
