PROBLEM TO BE SOLVED: To provide a detection method for bone metabolism disorder using genes strongly expressed in osteoclasts； to provide a screening method for the compound having effects on treating and/or preventing bone metabolism disorder； and to provide a pharmaceutical composition for the treatment and/or prevention of bone metabolism disorder.SOLUTION: The invention provides a detection method for bone metabolism disorder using the expression of a human Siglec-15 gene as an indicator, and a pharmaceutical composition containing antibodies having the activity which inhibits the formation of osteoclasts by specifically recognizing human Siglec-15.SELECTED DRAWING: None【課題】 破骨細胞で強く発現する遺伝子を用いた骨代謝異常の検出方法、骨代謝異常治療及び／又は予防効果を有する化合物のスクリーニング法、及び骨代謝異常治療及び／又は予防用医薬組成物を提供すること。【解決手段】 ヒトＳｉｇｌｅｃ－１５遺伝子の発現を指標とした骨代謝異常の検出方法、及びヒトＳｉｇｌｅｃ－１５を特異的に認識し、破骨細胞の形成を抑制する活性を有する抗体を含む医薬組成物の提供等。【選択図】 なし
