#$%^&*AU2015204305A120150806.pdf#####ABSTRACT This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity e.g., endoglucanase, cellobiohydrolase, mannanase and/or p-glucosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides having cellulase activity, e.g., endoglucanase, cellobiohydrolase, mannanase and/or p-glucosidase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes polypeptides, and making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts.