Crosslinked compositions useful for repairing, regenerating, and/or augmenting tissue, as well as acting as a biological scaffold that promotes cell in-growth and tissue integration, are disclosed, as are quick-setting, injectable precursors of such crosslinked compositions. Such crosslinked compositions generally comprise (1) a crosslinked tyramine-substituted hyaluronic acid and (2) an acellular tissue matrix. Also disclosed are methods of repairing, regenerating, and/or augmenting tissues using such crosslinked compositions, particularly voids in human tissue such as anal fistulae.
