An object of the present invention is to provide a medicine obtained by combining a liposome composition containing gemcitabine in a dissolved state in a liposome and an immune checkpoint inhibitor. According to the present invention, a medicine combining (A) liposome composition and (B) immune checkpoint inhibitor simultaneously or sequentially can be provided. A liposome composition of an aqueous solution of dispersed liposomes constituting the outer aqueous phase, in which the liposome contains gemcitabine in a dissolved state.本發明的課題為提供一種將脂質體內含溶解狀態的吉西他濱(gemcitabine)之脂質體組成物及免疫檢查點抑制劑組合而得到之醫藥。依本發明，可提供一種將(A)脂質體組成物及(B)免疫檢查點抑制劑組合而同時或依次之醫藥，該(A)脂質體組成物係含有具有內水相之脂質體和構成外水相之分散脂質體之水溶液之脂質體組成物，其中脂質體內含溶解狀態的吉西他濱。
