The present invention provides methods for antigen and/or bioactive molecule delivery to antigen presenting cells utilizing ASC specks as vehicles； 1) the ASC speck composition is made of ASC protein(s) and the antigen and/or bioactive molecule(s) purified from cells as a compact micro-spherical structure； 2) purified micro-spherical ASC speck delivery vehicles are stable at 37° C. for more than 30 days； and 3) antigen and/or bioactive molecules carried by ASC specks can be efficiently phagocytosed by antigen presenting cells and their degradation in the lysosome allows antigen processing and presentation.
