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Autotaxin inhibitors
专利权人:
Abby Louise Parrill-Baker
发明人:
Abby Louise Parrill-Baker,Daniel Lee Baker
申请号:
US12270840
公开号:
US08268891B1
申请日:
2008.11.13
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include thioureas, diphenyldiazerenes, xanthenes, and isoindoles and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.
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中国工程科技知识中心
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http://www.ckcest.cn/home/
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