PROCEDE DE PREPARATION DE METABOLITES DE (4S) ET (4R)- 4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTYRIDINE-3-CARBOXAMIDE ET LEUR UTILISATION

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专利权人:

BAYER PHARMA AKTIENGESELLSCHAFT

发明人:

PLATZEK, JOHANNES,ZORN, LUDWIG

申请号：

CA2995887

公开号：

CA2995887A1

申请日:

2016.08.15

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

The present invention relates to a novel method for the preparation of (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula 4R (I) and the metabolites of (4S)- and (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I), of the formulae M1a (S), M1b (R), M2a (S), M2b (R), M3a (S) and M3b (R) and the use thereof.

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