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A PROCESS FOR PREPARING A 2-(N-METHYL-N-METHANESULFONYLAMINO)PYRIMIDINE COMPOUND
专利权人:
发明人:
AKIO MATSUSHITA,MIZUHO ODA,YASUHIRO KA WACHI,JUN ICHI CHIKA
申请号:
IN8071/DELNP/2010
公开号:
IN2010DN08071A
申请日:
2010.11.16
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
<;p>;A 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound of the formula (3): [R is a hydrocarbyl group], is prepared by the steps of: (I) reacting an isobutyrylacetate ester with 4-fluorobenzaldehyde and urea in the presence of a protonic compound and a metal salt; (II) oxidizing the reaction product of the step (I); (III) reacting the oxidation product of the step (II) with an organic sulfonyl halide or an organic sulfonyl anhydride; and (IV) reacting the reaction product of the step (III) with N-methyl-N-methanesulfonamide.<;/p>;[WO03006439A1]
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