作為心血管疾病所用藥物之２－及／或４－經取代的雄固烷和雄固烯的胺基肟衍生物农业专利-农业专业知识服务系统

发明人:: CERRI, ALBERTO,谢瑞　艾伯特,謝瑞　艾伯特,FEDRIZZI, GIORGIO,菲德瑞兹　乔吉欧,菲德瑞茲　喬吉歐,BIANCHI, GIUSEPPE,毕恩奇　吉斯普,畢恩奇　吉斯普,FERRARI, PATRIZIA,费瑞　派希吉亚,費瑞　派希吉亞,GOBBINI, MAURO,格比尼　马罗,格比尼　馬羅,MARAZZI, GIUSEPPE,玛拉奇　吉瑟普,瑪拉奇　吉瑟普,TORR,谢瑞艾伯特,謝瑞艾伯特,菲德瑞兹乔吉欧,菲德瑞茲喬吉歐,毕恩奇吉斯普,畢恩奇吉斯普,费瑞派希吉亚,費瑞派希吉亞,格比尼马罗,格比尼馬羅,玛拉奇吉瑟普,瑪拉奇吉瑟普

摘要：: New aminooxime derivatives at position 3 of 2- and/or 4- substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I)are described, where the radicals have the meanings described in detail in the application.本發明揭示2-及/或4-經取代的雄固烷和雄固烯於第3位置上之新穎的胺基肟衍生物、製備彼等之方法及用於治療心血管疾病(諸如心力衰竭和高血壓)的含彼等之醫藥組成物。特別地，本發明描述通式(I)化合物其中基團之意義係詳細地敘述於說明書中。