Matthew Wook Chang,Tat Ming Samuel Lo,Chueh Loo Poh
申请号：
US14409227
公开号：
US10683521B2
申请日:
2013.06.12
申请国别(地区):
US
年份:
2020
代理人:
摘要：
An Expression system； isolated nucleic acid molecule or host cell comprising: (i) A first gene encoding for a first enzyme linked to a first promoter, wherein the first promoter is a time delay promoter； (ii) A second gene encoding for a second enzyme capable of using the product generated by the first enzyme as a substrate, wherein the second gene is operably linked to a second promoter, wherein the second promoter is inducible by the product generated by the first enzyme； (iii) Optionally, a third gene encoding a transcription factor that represses expression of the second gene in the absence of the product generated by the first enzyme, wherein the third gene is operably linked to a third promoter that regulates expression of the third gene； and its use in producing a product such as hydroxybenzaldehyde.
