CURTIN, MICHAEL L.,SORENSEN, BRYAN K.,HEYMAN, HOWARD R.,CLARK, RICHARD F.,WOLLER, KEVIN R.,SHAH, OMAR J.,MICHAELIDES, MICHAEL,TSE, CHRIS,VASUDEVAN, ANIL,MACK, HELMUT,HANSEN, TODD M.,SWEIS, RAMZI,PLIUS
申请号：
PE2013001089
公开号：
PE20140913A1
申请日:
2011.11.11
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to isomerization molding compound (IC), in which x1, X2 and X3 are ch, n or CR1 respectively, R1 is R3, R3, s (o) R3, C (o) NH2, etc.； R3 is tar, alquenilo, arilo, etc.； R2 is tar, phenyl, cyclopentanediol, etc. Phenyl phenyl phenyl phenyl phenyl phenyl phenyl phenyl phenyl phenyl phenyl phenyl phenyl methyl 1 (b)There are others He also mentioned a pharmaceutical composer These compounds are nicotine phosphate aryl transfer inhibitors or visfatina, which are used in the treatment of hypertension, heart failure and restorative health.SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (Ic) DONDE X1, X2 Y X3 SON CADA UNO CH, N O CR1, EN DONDE R1 ES R3, OR3, S(O)R3, C(O)NH2, ENTRE OTROS； R3 ES ALQUILO, ALQUENILO, ARILO, ENTRE OTROS； R2 ES ALQUILO, FENILO, CICLOALQUILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-{4-[(3-FENILPROPIL)CARBAMOIL]FENIL}-1,3-DIHIDRO-2H-ISOINDOL-2-CARBOXAMIDA； N-(4-{[4-(AMINOMETIL)BENCIL]CARBAMOIL}FENIL)-5-FLUORO-1,3-DIHIDRO-2H-ISOINDOL-2-CARBOXAMIDA； 5-CIANO-N-{4-[(3-FENILPROPIL)CARBAMOIL]FENIL}-1,3-DIHIDRO-2H-ISOINDOL-2-CARBOXAMIDA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE FOSFORIBOSILTRANSFERASA DE NICOTINAMIDA (NAMPT) O VISFATINA SIENDO UTILES EN EL TRATAMIENTO DE HIPERTENSION, INSUFICIENCIA CARDIACA, RESTENOSIS
