Rozema, David B.,Wakefield, Darren H.,Chen, Weijun,Almeida, Lauren J.,Blokhin, Andrei V.,Carlson, Jeffrey C.,Nicholas, Anthony L.,Almeida, Aaron,Kanner, Steven B.,Benson, Jonathan D.,Woods, Ju
申请号：
AU2016270593
公开号：
AU2016270593A1
申请日:
2016.05.27
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2α (EPAS1) gene are described. Pharmaceutical compositions comprising one or more HifZα RNAi triggers optionally with one or more additional therapeutics are also described. Delivery of the described Hif2α RNAi triggers to tumor cells in vivo provides for inhibition of Hif2α gene expression and treatment of cancer.
