A medical treatment method includes administering to a recipient a first composition comprising dendritic cells (DC) which are immunologically compatible with the recipient and which are associated with a target antigen. The method also includes administering to the recipient a second composition comprising at least a portion of the target antigen in soluble form and a co-stimulatory antibody effective for activating T-cells and/or the dendritic cells (DC), wherein the second composition is administered at least 1 day subsequent to administration of the first composition. The dendritic cells are preferably autologous dendritic cells.
