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8-substituted 2-amino- [1,2,4] triazolo [1,5-a] pyrazines as SYK tyrosine kinase inhibitors and GCN2 serine kinase inhibitors
- 专利权人:
- Merck Patent GmbH
- 发明人:
- DEUTSCH, Carl,KUHN, Daniel,ROSS, Tatjana,BURGDORF, Lars
- 申请号：
- ES13700849
- 公开号：
- ES2674451T3
- 申请日:
- 2013.01.22
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要：
- Compounds selected from the group 3,3-dimethyl-6- [8- (2-oxa-6-aza-spiro [3.4] oct-6-yl) - [1,2,4] triazolo [1,5-a] pyrazin-2-ylamino] -1,3-dihydro-indole-2-one ("C81"), 3,3-dimethyl-6- [8- (2-oxa-6-aza-spiro [3.3] hept- 6-yl) - [1,2,4] triazolo [1,5-a] pyrazin-2-ylamino] -1,3-dihydro-indole-2-one ("C91"), 3,3-dimethyl- 6- [8- (2-oxa-6-aza-spiro [3.5] non-6-yl) - [1,2,4] triazolo [1,5-a] pyrazin-2-ylamino] -1.3 -dihydro-indole-2-one ("C92"), 7- [2- (3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-6-ylamino) - [1,2, 4] triazolo [1,5-a] pyrazin-8-yl] -2,7-diaza-spiro [4.4] nonano-1,3-dione ("C95"), 7- [2- (3,3- dimethyl-2-oxo-2,3-dihydro-1H-indole-6-ylamino) - [1,2,4] triazolo [1,5-a] pyrazin-8-yl] -1,3,7-triaza -spiro [4.4] nonano- 2,4-dione ("C108"), 2- [2- (3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-6-ylamino) - [ 1,2,4] triazolo [1,5-a] pyrazin-8-yl] -2,5,7-triaza-spiro [3.4] octane- 6,8-dione ("C109"), 7- [2 - (3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indole-6-ylamino) - [1,2,4] triazolo [1,5-a] pyrazin-8-yl] -1 , 3,7-triaza-spiro [4.5] decane-2,4-dione ("C110"), 7- [2- (4,4-dimethyl -2-oxo-1,4-dihydro-2H-benzo [d] [1,3] oxazin-7-ylamino) - [1,2,4] triazolo [1,5-a] pyrazin-8-yl] -1,3,7-triazaspiro [4.4] nonano-2,4-dione ("C118"), 7- [2- (4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro- quinolin-7-ylamino) - [1,2,4] triazolo [1,5-a] pyrazin-8-yl] -2,7-diazaspiro [4.4] nonano-1,3-dione ("C127"), [8- (2,7-diaza-spiro [4.4] non-2-yl) - [1,2,4] triazolo [1,5-a] pyrazin-2-yl] - (4,4-dimethyl- 1,2,3,4-tetrahydro-quinolin-7-yl) -amine ("C129"), 6- [8- (1,4-dioxa-7-aza-spiro [4.4] non-7-yl) - [1,2,4] triazolo [1,5-a] pyrazin-2-ylamino] -3,3-dimethyl-1,3-dihydro-indole-2-one ("C130"), 8- [2 - (3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indole-6-ylamino) - [1,2,4] triazolo [1,5-a] pyrazin-8-yl] -2 , 8-diaza-spiro [4.5] decan-1- one ("C133"), (R) -7- [2- (3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole- 6-ylamino) - [1,2,4] triazolo [1,5-a] pyrazin-8-yl] -2,7-diazaspiro [4.4] nonano-1,3-dione ("C136"), (S ) -7- [2-
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
