Systems and methods are provided for monitoring medication compliance to allow a doctor or medical care provider to determine whether a subject is ingesting a prescribed medication at the proper times. A medication container includes at least one medication-containing cell, with a cover overlaying the cell. The medication within the cell is accessed through the cover. The medication container also includes an electrical circuit having an RFID chip electrically coupled to an antenna. The RFID chip is associated with the cover, while the antenna is configured to communicate with an RFID reader to detect whether the cell has been accessed through the cover. The RFID chip may be uncoupled from the antenna or remain coupled to the antenna upon the cell being accessed through the cover, with the antenna thereafter transmitting a signal to an RFID reader to indicate that the cell has been accessed through the cover.
