Sagar Raj Shakya;Anthony C. Blackburn;John A. DeMattei;Tsung-Hsun Chuang
发明人:
Anthony C. Blackburn,Sagar Raj Shakya,John A. DeMattei,Tsung-Hsun Chuang
申请号：
US13497616
公开号：
US20120225937A1
申请日:
2010.09.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to salts of 2-(2-((4-(((4-chlorophenyl)(phenyl)-carbamoyloxy)methyl)cyclohexyl)methoxy)acetamido)ethanesulfonic acid (Compound 1) and crystalline forms, solvates and hydrates thereof. The present invention further relates to processes and intermediates useful in the preparation of Compound I and salts, solvates and hydrates thereof. Crystalline forms, salts, solvates and hydrates of the present invention and pharmaceutical compositions thereof are useful in the treatment of for example, pulmonary arterial hypertension (PAH)； platelet aggregation； coronary artery disease； myocardial infarction； transient ischemic attack； angina； stroke； ischemia-reperfusion injury； restenosis； atrial fibrillation； blood clot formation； atherothrombosis； asthma or a symptom thereof； a diabetic-related disorder； glaucoma or other disease of the eye with abnormal intraocular pressure； hypertension； inflammation； psoriasis； psoriatic arthritis； rheumatoid arthritis； Crohn's disease； transplant rejection； multiple sclerosis； systemic lupus erythematosus (SLE)； ulcerative colitis； atherosclerosis； acne； type I diabetes； type 2 diabetes； sepsis； and chronic obstructive pulmonary disorder (COPD).
