The disclosure provides antibody agents that bind to a T Cell Immunoglobulin and Mucin Protein-3 (TIM-3) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided are related nucleic acids, vectors, compositions, and methods of using the anti-TIM-3 antibody agent to treat a disorder or disease that is responsive to TIM-3 inhibition, such as cancer, an infectious disease, or an autoimmune disease.本案揭示內容提供與T細胞免疫球蛋白及黏蛋白-3 (TIM-3)蛋白質結合之抗體藥劑。明確提供特定免疫球蛋白重鏈多肽及免疫球蛋白輕鏈多肽序列。亦提供相關核酸、載體、組成物及使用抗TIM-3抗體藥劑治療對TIM-3抑制起反應之病症或疾病(諸如癌症、感染性疾病或自體免疫疾病)的方法。
