#$%^&*AU2013205471B220160211.pdf#####ABSTRACT A metal coordination complex of a biologically active moiety and a metal is disclosed. The complex confers to the biologically active moeity an improved performance which can include potency, stability, absorbability, targeted delivery, and combinations thereof.WO 2007/050181 PCTfUS2006/031757 4/20 Base 0 OR OOH RO O ,OR 0 O- z0 Mg 0 -* OR R = Rest of RNA molecule Base = Purine or pyrimidine Inner sphere RNA:Magnesium Coordination Complex FIG. 6