PROBLEM TO BE SOLVED: To prepare liquid formulations containing both IGF-1 and growth hormone (GH), which are stable at 4°C for at least 30 days, with no significant aggregation as evidenced by visual clarity of the solution.SOLUTION: In accordance with the present invention, the pharmaceutical composition comprises IGF-1, GH and the following agents: a non-aggregating agent； a buffer； a surfactant； optionally a preservative； and optionally a tonicity modifier or bulking agent, wherein the non-aggregating agent is present in the composition in a concentration of at least 80 mM.SELECTED DRAWING: None【課題】ＩＧＦ－１と成長ホルモン(ＧＨ)の両者を含む液体配合物であって、４℃で少なくとも３０日間安定であり、溶液が視覚的に澄んでいることにより証明されるように有意の凝集物を含まない当該液体配合物を製造すること。【解決手段】ＩＧＦ－１とＧＨと下記を含む医薬組成物非凝集剤；緩衝剤；界面活性剤；任意の防腐剤；及び任意の浸透圧調節剤又は増量剤(但し、非凝集剤は、組成物中に、少なくとも約８０ｍＭの濃度で存在する)。【選択図】なし
